Matthias Geyer studied Physics in Kiel, Bonn, and Heidelberg and graduated in Biophysics at the Max Planck Institute for Medical Research in Heidelberg. Working in the department of Kenneth C. Holmes he was trained in structural biology with an emphasis on the analysis of nucleotide-binding proteins. In 1999 he moved as a research assistant to the HHMI laboratory of Matija Peterlin at UCSF. Coming back to Germany, he spent 10 years as an independent research group leader within the Max Planck Society, working at the Max Planck Institute of Molecular Physiology, Dortmund, and the Research Center caesar, Bonn. He obtained the habilitation in biochemistry from the Medical Faculty at Heidelberg University. In 2014, he joined the Institute of Innate Immunity at the University of Bonn setting up a research department in biochemistry and structural biology. Since 2015 he is a core member of the excellence cluster ImmunoSensation and appointed to the cluster chair for Structural Immunology. Dr. Geyer is using a broad range of biochemical methods to determine protein–protein interactions as well as the interaction to lipids, nucleic acids, and small molecular ligands. His laboratory is applying X-ray crystallography, NMR spectroscopy, and electron microscopy for the structural analysis of protein complexes. His group investigates the activation and formation of the inflammasome, the regulation of eukaryotic transcription, and the remodelling of the actin cytoskeleton.